Sodium Acetate → 3,3,3-Trifluoro-2-oxopropanal (4-chloro-2-fluoro-5-hydroxyphenylhydrazone)

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Reaction Steps

Then, 49.2 g of sodium acetate and 40.5 g of 1,1-dibromo-3,3,3-trifluoroacetone were dissolved in 400 ml of water, and the solution was heated at 80° to 90° C. for 40 minutes. This solution was cooled to 0° C., to which 75 g of the crude crystals of 2-fluoro-4-chloro-5-hydroxyphenylhydrazine hydrochloride was added. The mixture was stirred at room temperature for 70 minutes, and the resulting crystals were collected by filtration, and dried under reduced pressure, which afforded 35.4 g of 3,3,3-trifluoro-2-oxopropanal 1-(4-chloro-2-fluoro-5-hydroxyphenylhydrazone).

Provenance & Evidence