Tert-Butyl nitrite → HCID 18689526, compound

Participants

Reaction Steps

10.7 g (0.0667 mol) of bromine were added at 25° C. with stirring in the course of 10 minutes to 9.3 g (0.029 mol) of the compound from Example 3 in 200 ml of chloroform; 4.5 g [0.0435 mol] of tert-butyl nitrite were then added in the course of 5 minutes at the same temperature and the mixture was subsequently stirred for 14 hours. The reaction solution was stirred into 1 l of ice water and then extracted with methylene chloride. The organic extract was washed in the customary manner and dried, filtered off with suction through neutral alumina and concentrated under reduced pressure. After triturating in ether/pentane, filtering off with suction and drying, 4.0 9 (35.7% of theory) of the title compound of m.p. 121-122° C. were obtained (Active Compound Example No. 2a.022).

Provenance & Evidence