Benzyl Bromide → HCID 5329783, compound

Participants

Reaction Steps

To a solution of [4-hydroxy-1H-pyrazolo[3,4-b]pyridin-5-yl]phenylmethanone (50 mg, 0.21 mmol) in methanol (1 mL) and saturated aqueous NaHCO3 solution (10 mL) was added benzyl bromide (0.027 mL, 0.23 mmol). The reaction mixture was stirred at room temperature for 16 h and extracted with CH2Cl2 (3×10 mL). The combined organic layers were dried (Na2SO4) and concentrated in vacuo to give an oil. The crude material was purified by flash chromatography (SiO2, 230-400 mesh, eluted with 1:19 MEOH/CH2Cl2) to afford the title compound (13 mg, 20%) as a white solid.

Provenance & Evidence