3-(Isoquinolin-4-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene → HCID 18689915, compound

HRID 1871918Notes

Reaction equation

HRID 1871918 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[CH2:17][CH:16]3[N:18]([CH3:19])[CH:13]([CH2:14][CH2:15]3)[CH:12]=2)=[CH:3][N:2]=1>CO>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]2[CH2:17][CH:16]3[N:18]([CH3:19])[CH:13]([CH2:14][CH2:15]3)[CH2:12]2)=[CH:3][N:2]=1

Participants

3

Reactant 1

HCID 186899123-(Isoquinolin-4-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene

Product 1

HCID 18689915HCID 18689915, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture 3-(isoquinolin-4-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene and 5-palladium on carbon in methanol is stirred at room temperature for 3 days under a hydrogen atmosphere. The reaction mixture is then filtered and the filtrate concentrated under reduced pressure. The residue is subjected to flash silica gel chromatography. Fractions containing product are combined and concentrated under reduced pressure to provide the title compound.

Workup

  1. filtrationThe reaction mixture is then filtered
  2. concentrationthe filtrate concentrated under reduced pressure
  3. additionFractions containing product
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3c41574f66b346e8af0f395970b1a62f
Source dataset
uspto-grants-2000_08
Patent number
US06107307

Reaction notes

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