Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3,6-Dichloropyridazine | HCID 67331 | — |
| Reactant | 5-(5h-Dibenzo[a,d]cyclohepten-5-yl)-2,4(1h,3h)-pyrimidinedione | HCID 11098675 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 18689771 | HCID 18689771 | — |
Reaction Steps
Cesium carbonate (2.15 g) was added to a stirred solution of the product of example 1 step (iv) (2 g) in dimethylsulphoxide (20 ml). After 5 minutes 3,6-dichloropyridazine (1 g) was added and the mixture heated at 80° C. for 3 hours. The mixture was partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated. The residue was purified by chromatography eluting with 50% ethyl acetate in isohexane. Yield 1.8 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06107297 |
|---|
| Source dataset | uspto-grants-2000_08 |
|---|
| ORD ID | ord-823292e78aeb4bb6b6c6815cce31c163 |
|---|
| Source note | uspto-grants-2000_08 |
|---|
