methyl L-prolinate hydrochloride → HCID 131721949, compound

HRID 1871977Notes

Reaction equation

HRID 1871977 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH:13]=[C:12]([CH:14]3[C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=4[CH:18]=[CH:17][C:16]4[CH:25]=[CH:26][CH:27]=[CH:28][C:15]3=4)[C:11](=[O:29])[NH:10][C:9]2=[O:30])[CH:5]=[CH:4][N:3]=1.Cl.[CH3:32][O:33][C:34](=[O:40])[C@@H:35]1[CH2:39][CH2:38][CH2:37][NH:36]1>>[CH:24]1[C:19]2[CH:18]=[CH:17][C:16]3[CH:25]=[CH:26][CH:27]=[CH:28][C:15]=3[CH:14]([C:12]3[C:11](=[O:29])[NH:10][C:9](=[O:30])[N:8]([C:6]4[CH:5]=[CH:4][N:3]=[C:2]([N:36]5[CH2:37][CH2:38][CH2:39][C@H:35]5[C:34]([O:33][CH3:32])=[O:40])[N:7]=4)[CH:13]=3)[C:20]=2[CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 2733200methyl L-prolinate hydrochlorideHCID 18689687HCID 18689687, compound

Product 1

HCID 131721949HCID 131721949, compound

Procedure

The subtitle compound was prepared from the product of example 6 step (i) (0.3 g) and L-proline methyl ester hydrochloride (0.6 g) by the method of example 10 step (ii). Purification was by chromatography eluting with 5% methanol in dichloromethane. Yield 0.55 g.

Workup

  1. customPurification
  2. washeluting with 5% methanol in dichloromethane

Sources & evidence

ORD record
ord-3f098ad3526b4eec9746017b87d20be3
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

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