HRID1871978

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2733200

未命名化合物

结构：Cc1ccc2c(c1)C=Cc1cc(C)ccc1C2c1cn(-c2ccnc(Cl)n2)c(=O)[nH]c1=O

HCID18689750

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@@H]1CCCN1c1nccc(-n2cc(C3c4ccc(C)cc4C=Cc4cc(C)ccc43)c(=O)[nH]c2=O)n1

HCID131721950

未命名化合物

PROCEDURE

实验过程

The subtitle compound was prepared from the product of example 8 step (ii) (0.3 g) and L-proline methyl ester hydrochloride (0.56 g) by the method of example 10 step (ii). Purification was by chromatography eluting with 5% methanol in chloroform. Yield 0.3 g.

WORKUP

后处理

customPurification
washeluting with 5% methanol in chloroform

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-17ce48c7c5104f799be6250e74f7b1db
来源数据集: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06107297
来源说明: uspto-grants-2000_08

反应 SMILES

Cl[C:2]1[N:7]=[C:6]([N:8]2[CH:13]=[C:12]([CH:14]3[C:20]4[CH:21]=[CH:22][C:23]([CH3:25])=[CH:24][C:19]=4[CH:18]=[CH:17][C:16]4[CH:26]=[C:27]([CH3:30])[CH:28]=[CH:29][C:15]3=4)[C:11](=[O:31])[NH:10][C:9]2=[O:32])[CH:5]=[CH:4][N:3]=1.Cl.[CH3:34][O:35][C:36](=[O:42])[C@@H:37]1[CH2:41][CH2:40][CH2:39][NH:38]1>>[CH3:25][C:23]1[CH:22]=[CH:21][C:20]2[CH:14]([C:12]3[C:11](=[O:31])[NH:10][C:9](=[O:32])[N:8]([C:6]4[CH:5]=[CH:4][N:3]=[C:2]([N:38]5[CH2:39][CH2:40][CH2:41][C@H:37]5[C:36]([O:35][CH3:34])=[O:42])[N:7]=4)[CH:13]=3)[C:15]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:16]=3[CH:17]=[CH:18][C:19]=2[CH:24]=1