HCID 22117225, compound → HCID 22117207, compound

HRID 1871984Notes

Reaction equation

HRID 1871984 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]2[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:12]=2[C:13]([OH:15])=O)[CH:6]=[CH:7][CH:8]=1)[CH3:2]>S1(CCCC1)(=O)=O>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]2[C:13](=[O:15])[C:12]3[CH:16]=[CH:17][C:18]([CH3:20])=[CH:19][C:11]=3[CH2:10][CH2:9][C:5]=2[CH:4]=1)[CH3:2]

Participants

3

Reactant 1

HCID 22117225HCID 22117225, compound

Product 1

HCID 22117207HCID 22117207, compound

Reagents, catalysts & solvents 1

HCID 31347SulfolaneSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of the product from step (v) in polyphosphoric acid (40 g) and sulpholane (20 ml) was heated at 130° C. for 5 hours and partitioned between ethyl acetate and water. The organic phase was washed with aqueous sodium bicarbonate and water, dried (MgSO4) and evaporated. Purified by chromatography eluting with 5% ethyl acetate in isohexane.

Workup

  1. custompartitioned between ethyl acetate and water
  2. washThe organic phase was washed with aqueous sodium bicarbonate and water
  3. dry with materialdried (MgSO4)
  4. customevaporated
  5. customPurified by chromatography
  6. washeluting with 5% ethyl acetate in isohexane

Sources & evidence

ORD record
ord-3f5a8a69711643ec9113411c0ab5bb6d
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

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