3-azetidinecarboxylic Acid → HCID 18689745, compound

HRID 1871997Notes

Reaction equation

HRID 1871997 reaction equation
[CH2:1]([C:3]1[CH:46]=[CH:45][C:6]2[CH:7]([C:17]3[C:18](=[O:44])[NH:19][C:20](=[O:43])[N:21]([C:23]4[CH:28]=[CH:27][N:26]=[C:25]([NH:29][CH2:30]C(NC5SC=C(CC(O)=O)N=5)=O)[N:24]=4)[CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2].N1C[CH:49]([C:51]([OH:53])=[O:52])[CH2:48]1>>[CH2:1]([C:3]1[CH:46]=[CH:45][C:6]2[CH:7]([C:17]3[C:18](=[O:44])[NH:19][C:20](=[O:43])[N:21]([C:23]4[CH:28]=[CH:27][N:26]=[C:25]([N:29]5[CH2:48][CH:49]([C:51]([OH:53])=[O:52])[CH2:30]5)[N:24]=4)[CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 931923-azetidinecarboxylic AcidHCID 54523132HCID 54523132, compound

Product 1

HCID 18689745HCID 18689745, compound

Procedure

The title compound was prepared from the product of example 15 step (viii) (0.2 g) and 3-azetidinecarboxylic acid (0.045 g) by the method of example 7 step (i). Purification was by precipitation with ethyl acetate/isohexane and filtration. Yield 0.14 g.

Workup

  1. customPurification
  2. customwas by precipitation with ethyl acetate/isohexane and filtration

Sources & evidence

ORD record
ord-f02071fc59c641d3ae5f4a09c58fd44d
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

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