Methyl iodide → HCID 68585211, compound

HRID 18720Notes

Reaction equation

HRID 18720 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:8]2[C@@H:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=3)[NH:11][C:10](=[S:20])[NH:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:21][I:22]>CCO>[IH:22].[Cl:19][C:15]1[CH:14]=[C:13]([C@H:12]2[C@@H:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[NH:9][C:10]([S:20][CH3:21])=[N:11]2)[CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 86596318HCID 86596318, compound

Product 1

HCID 68585211HCID 68585211, compoundYield 85.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of cis-4,5-bis-(3-chlorophenyl)imidazolidine-2-thione (33) (8.23 g, 0.0254 mol) and methyl iodide (3.17 mL, 0.0509 mol) in abs. EtOH (25 mL) is heated at 90° C. for 8 h. The reaction mixture is cooled to rt, concentrated in vacuo, and the residue triturated with abs EtOH. The insoluble material is filtered to give 10.1 g of the product 50.

Workup

  1. concentrationconcentrated in vacuo
  2. customthe residue triturated with abs EtOH
  3. filtrationThe insoluble material is filtered

Sources & evidence

ORD record
ord-1cf09617e1f04ec38eaf060daaba8998
Source dataset
uspto-grants-2010_06
Patent number
US07741493B2

Reaction notes

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