methyl L-prolinate hydrochloride → HCID 131721954, compound

HRID 1872000Notes

Reaction equation

HRID 1872000 reaction equation
[CH2:1]([C:3]1[CH:46]=[CH:45][C:6]2[CH:7]([C:17]3[C:18](=[O:44])[NH:19][C:20](=[O:43])[N:21]([C:23]4[CH:28]=[CH:27][N:26]=[C:25](NCC(NC5SC=C(CC(O)=O)N=5)=O)[N:24]=4)[CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2].Cl.[CH3:48][O:49][C:50](=[O:56])[C@@H:51]1[CH2:55][CH2:54][CH2:53][NH:52]1>>[CH2:1]([C:3]1[CH:46]=[CH:45][C:6]2[CH:7]([C:17]3[C:18](=[O:44])[NH:19][C:20](=[O:43])[N:21]([C:23]4[CH:28]=[CH:27][N:26]=[C:25]([N:52]5[CH2:53][CH2:54][CH2:55][C@H:51]5[C:50]([O:49][CH3:48])=[O:56])[N:24]=4)[CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 2733200methyl L-prolinate hydrochlorideHCID 54523132HCID 54523132, compound

Product 1

HCID 131721954HCID 131721954, compound

Procedure

The subtitle compound was prepared from the product of example 15 step (viii) (0.5 g) and L-proline methyl ester hydrochloride (0.265 g) by the method of example 10 step (ii). Purification was by chromatography eluting with 40% ethyl acetate in isohexane. Yield 0.47 g.

Workup

  1. customPurification
  2. washeluting with 40% ethyl acetate in isohexane

Sources & evidence

ORD record
ord-21e9098e3ddf4a9c85a4b35401b899d5
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

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