2,6-Lutidine → Ethyl 4-oxobutanoate

Participants

Reaction Steps

Ethyl succinyl cloride (4.1 g) was added to a suspension of 10% palladium on carbon (0.3 g) and 2,6-lutidine (2.9 ml) in dry tetrahydrofuran (100 ml). The mixture was hydrogenated at 3 atmospheres pressure for 24 hours. The reaction mixture was filtered and the filtrate evaporated under reduced pressure. Yield 3.15 g. 1H NMR: δ (CDCl3) 9.82 (s,1H), 4.16 (q,2H), 2.80 (t,2H), 2.63 (t,2H), 1.26 (t,3H).

Provenance & Evidence