HCID 54346807, compound → HCID 131721955, compound

HRID 1872007Notes

Reaction equation

HRID 1872007 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[CH2:5][C:6]1[S:10][C:9]([NH:11][C:12](=[O:15])[CH2:13][NH2:14])=[N:8][CH:7]=1)[CH3:2].[CH2:17]([C:19]1[CH:62]=[CH:61][C:22]2[CH:23]([C:33]3[C:34](=[O:60])[NH:35][C:36](=[O:59])[N:37]([C:39]4[CH:44]=[CH:43][N:42]=[C:41](NCC(NC5SC=C(CC(O)=O)N=5)=O)[N:40]=4)[CH:38]=3)[C:24]3[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][C:25]=3[CH:26]=[CH:27][C:21]=2[CH:20]=1)[CH3:18]>>[CH2:17]([C:19]1[CH:62]=[CH:61][C:22]2[CH:23]([C:33]3[C:34](=[O:60])[NH:35][C:36](=[O:59])[N:37]([C:39]4[CH:44]=[CH:43][N:42]=[C:41]([NH:14][CH2:13][C:12]([NH:11][C:9]5[S:10][C:6]([CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:16])=[CH:7][N:8]=5)=[O:15])[N:40]=4)[CH:38]=3)[C:24]3[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][C:25]=3[CH:26]=[CH:27][C:21]=2[CH:20]=1)[CH3:18]

Participants

3

Reactant 2

HCID 54346807HCID 54346807, compoundHCID 54523132HCID 54523132, compound

Product 1

HCID 131721955HCID 131721955, compound

Procedure

The subtitle compound was prepared from the product of step (iv) (1.05 g) and the product from example 15 step (viii) (0.5 g) by the method of example 10 step (ii). Purification was by chromatography eluting with 66-100% ethyl acetate in toluene. Yield 0.27 g.

Workup

  1. customPurification
  2. washeluting with 66-100% ethyl acetate in toluene

Sources & evidence

ORD record
ord-8e885f0040de4dd19cb28e804871a304
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

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