HCID 18689711, compound → HCID 18689766, compound

HRID 1872008Notes

Reaction equation

HRID 1872008 reaction equation
C[O:2][C:3]1[CH:26]=[CH:25][C:6]2[CH:7]([C:17]3[C:18](=[O:24])[NH:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1>ClCCl>[OH:2][C:3]1[CH:26]=[CH:25][C:6]2[CH:7]([C:17]3[C:18](=[O:24])[NH:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1

Participants

3

Reactant 1

HCID 18689711HCID 18689711, compound

Product 1

HCID 18689766HCID 18689766, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of borontribromide (1.0M in dichloromethane) (10 ml) was added to a mixture of the product from example 23 step (iv) (1.4 g) in dichloromethane (20 ml). After stirring for 2 hours, the reaction mixture was partitioned between 2M hydrochloric acid and ethyl acetate. The organic layer was washed with water, dried (MgSO4) and evaporated under reduced pressure. Used directly in the next step.

Workup

  1. customthe reaction mixture was partitioned between 2M hydrochloric acid and ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried (MgSO4)
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-808de6cf6f374fda8e7ef2a6696a5917
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

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