Imidazole → HCID 18689727, compound

Participants

Reaction Steps

Tert-butyl dimethylsilylchloride (0.98 g) was added to a mixture of the product from step (i) and imidazole (0.74 g) in dimethylformamide (20 ml). The reaction mixture was stirred for 3 hours and partitioned between water and ethyl acetate. The organic layer was washed with water, dried (MgSO4) and evaporated under reduced pressure. Purification was by chromatography eluting with 50-70% ethyl acetate in isohexane. Yield 0.71 g.

Provenance & Evidence