2-Chloro-6-propylthio-4-pyrimidinecarboxylic acid, (1,1-dimethylethyl) ester → tert-Butyl 2-chloropyrimidine-4-carboxylate

Participants

Reaction Steps

To a suspension of Raney® nickel (50% slurry in water, 10 g) in ethanol (20 ml) was added a solution of the product from step (ii) (3.83 g) in ethanol (20 ml). The mixture was stirred for 2 hours and treated with a further 5 g Raney® nickel. The mixture was stirred overnight and treated with a further 20 g Raney® nickel. After 1 hour the reaction mixture was filtered through Kieselguhr and the filtrate evaporated. The residue was purified by chromatography eluting with 5-10% ethyl acetate in isohexane. Yield 1.3 g.

Provenance & Evidence