反应详情

To a solution of the product of step (i) (0.094 g) in trifluoroacetic acid (4 ml) under a nitrogen atmosphere was added 1-methyluracil (0.01 g), and the mixture stirred at room temperature for 1 hour. Evaporation of solvent afforded an orange oil which was azeotroped once with acetonitrile (5 ml). The crude product was redissolved in acetonitrile (2 ml), and stirred at room temperature for 0.5 h, giving a white precipitate. The reaction mixture was diluted with water (10 ml) and the white precipitate isolated by filtration. Yield: 0.085 g

1. customEvaporation of solvent
2. customafforded an orange oil which
3. customwas azeotroped once with acetonitrile (5 ml)
4. dissolutionThe crude product was redissolved in acetonitrile (2 ml)
5. stirringstirred at room temperature for 0.5 h
6. customgiving a white precipitate
7. customthe white precipitate isolated by filtration