HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Methylamino)ethanol → 2-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Methylamino)ethanol | HCID 8016 | — |
| Reactant | 2,4-Dichloro-6-methylpyrimidine | HCID 79471 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine | HCID 18323828 | 34.5% |
Reaction Steps
Part A: A solution of 2,4-dichloro-6-methylpyrimidine (1.0 g) and 2-(methylamino)ethanol (0.4 g) in ethanol (50 mL) was refluxed for 24 hours. The solvent was evaporated to give a crude residue, which was chromatographed on silica gel using 5% methanol in chloroform to yield 2-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine (370 mg). Mass spec. (NH3 --CI/DDIP): 202 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06107301 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-9e53ef8df98649d09dae668c32ef2d97 |
| Source note | uspto-grants-2000_08 |