Acetic Acid → 7-bromo-1-((tetrahydro-2H-pyran-4-yl)methyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

HRID 187205Notes

Reaction equation

HRID 187205 reaction equation
[Br:1][c:2]1[n:3][c:4]([NH:15][CH2:16][CH:17]2[CH2:18][CH2:19][O:20][CH2:21][CH2:22]2)[c:5]([NH:8][CH2:9][C:10](=[O:11])[O:12][CH2:13][CH3:14])[n:6][cH:7]1.[CH3:23][C:24](=[O:25])[OH:26]>>[Br:1][c:2]1[n:3][c:4]2[c:5]([n:6][cH:7]1)[NH:8][CH2:9][C:10](=[O:11])[N:15]2[CH2:16][CH:17]1[CH2:18][CH2:19][O:20][CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 86644641Ethyl 2-(5-bromo-3-((tetrahydro-2H-pyran-4-yl)methylamino)pyrazin-2-ylamino)acetate

Product 1

HCID 866446427-bromo-1-((tetrahydro-2H-pyran-4-yl)methyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

Sources & evidence

ORD record
ord-d5053a2f0cd04e1f94e6b537877826e2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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