Morpholine → HCID 15490844, compound

HRID 1872063Notes

Reaction equation

HRID 1872063 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[N:11]1[CH:19]=[N:18][C:17]2[C:12]1=[N:13][C:14]([CH3:21])=[N:15][C:16]=2Cl.[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>>[Br:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[N:11]1[CH:19]=[N:18][C:17]2[C:12]1=[N:13][C:14]([CH3:21])=[N:15][C:16]=2[N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 10546822HCID 10546822, compound

Product 1

HCID 15490844HCID 15490844, compound

Procedure

9[2-bromo-4(2-propyl)phenyl]-2-methyl-6-chloropurine (1.3 g) and morpholine (10 mL) were combined under nitrogen and refluxed for 6 hrs. The reaction mixture was concentrated by rotovap and the residue was purified by flash chromatography (CH2Cl2 :MeOH, 50:1, silica) to yield a yellow solid (0.54 g). MS (M+H)+ 416, 418.

Workup

  1. temperaturerefluxed for 6 hrs
  2. concentrationThe reaction mixture was concentrated by rotovap
  3. customthe residue was purified by flash chromatography (CH2Cl2 :MeOH, 50:1, silica)

Sources & evidence

ORD record
ord-56c30626bfe64ab1b8919a0bacb803a0
Source dataset
uspto-grants-2000_08
Patent number
US06107301

Reaction notes

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