反应详情

2,3-Dihydro-1'-methyl-5-nitrospiro[benzofuran-3,4'-piperidine](D4, 0.98 g, 4.0 mmol) was hydrogenated over 10% palladium on charcoal (0.18 g) in ethanol (50 ml) for 6 h. Catalyst was filtered off onto kieselguhr, and the filtrate was evaporated and chromatographed on silica gel, eluting with 0-25% methanol/chloroform (gradient), to give the title compound (0.52 g, 60%) as a cream solid.

1. filtrationCatalyst was filtered off onto kieselguhr
2. customthe filtrate was evaporated
3. customchromatographed on silica gel
4. washeluting with 0-25% methanol/chloroform (gradient)