1,3-Propanediamine, N1,N1,N3-trimethyl- → HCID 54143483, compound

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Reaction Steps

N,N,N'-Trimethyl-1,3-diaminopropane (0.31 mmol) and 2-[(5-chloro-1H-indole-2-carbonyl)-amino]-3-phenyl-propionic acid (0.28 mmol) were coupled according to Procedure A (0-25° C. reaction temperature, 120 hour reaction time) and the product purified by chromatography on silica gel eluted with 1-8% ethanol in dichloromethane containing 0.5% ammonium hydroxide: Yield 86 mg, 69%; HPLC (40/60) 7.57 minutes (>99%); mp 187-190.5° C.; TSPMS 441/443 (MH+, 100%);

Provenance & Evidence