HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine, hydrochloride → (s)-(1-Dimethylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | 2-((tert-Butoxycarbonyl)amino)-3-(thiazol-4-yl)propanoic acid | HCID 14540322 | — |
| Product | (s)-(1-Dimethylcarbamoyl-2-thiazol-4-yl-ethyl)-carbamic acid tert-butyl ester | HCID 54383962 | — |
Reaction Steps
Dimethylamine hydrochloride (1.2 mmol) and Boc-L-3-(4-thiazolyl)alanine (1.0 mmol) were coupled according to Procedure A (0-25° C. reaction temperature) and the product purified by chromatography on silica gel eluted with 1-16% ethanol in dichloromethane containing 0.5% ammonium hydroxide. Yield 124 mg, 41%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06107329 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-2631e8ec6d0c434798a7eec8c0cb97a8 |
| Source note | uspto-grants-2000_08 |