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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1872128Generated: October 31, 2026

1,4-Dioxane hydrochloride → (R)-2-Amino-1-(4-hydroxy-piperidin-1-yl)-3-phenyl-propan-1-one hydrochloride

https://huagongshe.com/reaction/1872128

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxane hydrochlorideHCID 20443148—
ReactantHCID 53842654HCID 53842654—
Product(R)-2-Amino-1-(4-hydroxy-piperidin-1-yl)-3-phenyl-propan-1-one hydrochlorideHCID 69687537—

Reaction Conditions

Temperature25 °C

Reaction Steps

(R)-2-(N-t-butoxycarbonylamino)-1-(4-hydroxy-piperidin-1-yl)-3-phenyl-propan-1-one (12.5 mmol) was dissolved in 4M HCl-dioxane at 0° C. and the resulting suspension stirred at 25° C. for 1 hour. The mixture was concentrated and the residue triturated with ether. Yield, 3.44 g, 97%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06107329
Source datasetuspto-grants-2000_08
ORD IDord-7d74f11d771a4d6dbb71b0a177e80f34
Source noteuspto-grants-2000_08