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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1872133Generated: October 31, 2026

1,4-Dioxane hydrochloride → (S)-2-Amino-3-(4-fluoro-phenyl)-1-morpholin-4-yl-propan-1-one hydrochloride

https://huagongshe.com/reaction/1872133

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxane hydrochlorideHCID 20443148—
Reactant(S)-2-(N-t-Butoxycarbonylamino)-3-(4-fluoro-phenyl)-1-morpholin-4-yl-propan-1-oneHCID 22865441—
Product(S)-2-Amino-3-(4-fluoro-phenyl)-1-morpholin-4-yl-propan-1-one hydrochlorideHCID 69687112—

Reaction Conditions

Temperature25 °C

Reaction Steps

(S)-2-(N-t-Butoxycarbonylamino)-3-(4-fluoro-phenyl)-1-morpholin-4-yl-propan-1-one (3.1 mmol) was dissolved in 4M HCl-dioxane at 0° C. and the resulting suspension stirred at 25° C. for 1 hour. The mixture was concentrated and the residue triturated with ether. Yield, 776 mg, 88%; HPLC (60/40) 2.31 minutes (99%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06107329
Source datasetuspto-grants-2000_08
ORD IDord-f4d9f50687234fad8d2d3e8059cc7718
Source noteuspto-grants-2000_08