5-Chloro-1H-indole-2-carboxylic acid → HCID 44450822, compound

Participants

Reaction Steps

(S)-2-Amino-3-(4-chloro-phenyl)-1-(4-hydroxy-piperidin-1-yl)-propan-1-one hydrochloride (0.98 mmol) and 5-chloro-1H-indole-2-carboxylic acid (0.92 mmol) were coupled according to Procedure A and the product purified by chromatography on silica gel eluted with 50, 75 and 100% ethyl acetate in hexanes. Yield 362 mg, 86%; HPLC (60/40) 5.06 minutes (97%); mp 227-229° C.; TSPMS 460/462 (MH+, 100%);

Provenance & Evidence