HCID 54265031, compound → HCID 69688622, compound

HRID 1872148Notes

Reaction equation

HRID 1872148 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1)[C:9]([N:11]1[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13][CH2:12]1)=[O:10])(C)(C)C>Cl.O1CCOCC1>[ClH:25].[NH2:7][C@@H:8]([CH2:18][C:19]1[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=1)[C:9]([N:11]1[CH2:12][CH2:13][CH:14]([OH:17])[CH2:15][CH2:16]1)=[O:10]

Participants

3

Reactant 1

HCID 54265031HCID 54265031, compound

Product 1

HCID 69688622HCID 69688622, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Conditions

Temperature
25 °C

Procedure

(S)-[1-(4-Chloro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl)-carbamic acid tert-butyl ester (475 mg, 1.2 mmol) was dissolved in 4M HCl-dioxane (5 mL) at 0° C. The mixture was stirred for 1.5 hour at 25° C., concentrated and the residue triturated with ether. Yield, 422 mg, 105%; TSPMS 283 (MH+, 100%).

Workup

  1. concentrationconcentrated
  2. customthe residue triturated with ether
  3. customYield

Sources & evidence

ORD record
ord-4f40993cc22c4e1380cd4fe17a13a125
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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