1,4-Dioxane hydrochloride → HCID 178479296, compound

HRID 1872149Notes

Reaction equation

HRID 1872149 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH2:18][C:19]1[N:20]=[CH:21][N:22](S(C2C=CC(C)=CC=2)(=O)=O)[CH:23]=1)[C:9]([N:11]1[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13][CH2:12]1)=[O:10])(C)(C)C.[ClH:35].O1CCOCC1>>[ClH:35].[NH2:7][C@@H:8]([CH2:18][C:19]1[N:20]=[CH:21][NH:22][CH:23]=1)[C:9]([N:11]1[CH2:12][CH2:13][CH:14]([OH:17])[CH2:15][CH2:16]1)=[O:10]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 69687638HCID 69687638, compound

Product 1

HCID 178479296HCID 178479296, compound

Conditions

Temperature
25 °C

Procedure

(S)-{2-(4-Hydroxy-piperidin-1-yl)-2-oxo-1-[1-(toluene-4-sulfonyl)-1H-imidazol-4-ylmethyl]-ethyl}-carbamic acid tert-butyl ester (512 mg, 1.0 mmol) was dissolved in 4 M HCl-dioxane (3 mL) at 0° C. The mixture was stirred at 25° C. for 1.5 hours, concentrated and the residue triturated with ether. Yield, 422 mg, 105%; TSPMS 283 (MH+, 100%).

Workup

  1. concentrationconcentrated
  2. customthe residue triturated with ether
  3. customYield

Sources & evidence

ORD record
ord-9f05742e9ac44eeaabe6d219abb18fd4
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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