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HRID1872158

反应详情

EQUATION

反应方程式

HRID 1872158 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)c1cc2cc(Cl)ccc2[nH]1
HCID82693

5-Chloroindole-2-carboxylate

C9H6ClNO2

结构：Cl.N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(O)CC1
HCID67279148

未命名化合物

PRODUCTS

生成物

1
结构：O=C(N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(O)CC1)c1cc2cc(Cl)ccc2[nH]1
HCID54502029

未命名化合物

PROCEDURE

实验过程

(R)-2-Amino-3-(4-fluoro-phenyl)-1-(4-hydroxy-piperidin-1-yl)-propan-1-one hydrochloride (0.6 mmol) and 5-chloro-1H-indole-2-carboxylic acid (0.6 mmol) were coupled according to Procedure A and the crude product purified by chromatography on silica gel eluted with 50, 75 and 100% ethyl acetate in hexanes. Yield 171 mg, 765%; HPLC (60/40) 4.23 minutes (97%); MS 444/446 (MH+, 100%); TSPMS 444/446 (MH+, 100%);

WORKUP

后处理

  1. customthe crude product purified by chromatography on silica gel
  2. washeluted with 50, 75 and 100% ethyl acetate in hexanes
  3. customHPLC (60/40) 4.23 minutes (97%)