1,4-Dioxane hydrochloride → HCID 86755675, compound

HRID 1872162Notes

Reaction equation

HRID 1872162 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:15](=[O:20])[N:16]([O:18][CH3:19])[CH3:17])[CH2:9][C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)(C)(C)C.[ClH:22].O1CCOCC1>>[ClH:22].[NH2:7][C@@H:8]([CH2:9][C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:15]([N:16]([O:18][CH3:19])[CH3:17])=[O:20]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22942149HCID 22942149, compound

Product 1

HCID 86755675HCID 86755675, compound

Conditions

Temperature
25 °C

Procedure

(S)-[1-(Methoxy-methyl-carbamoyl)-2-thiophen-2-yl-ethyl]-carbamic acid tert-butyl ester (1.3 mmol) was dissolved in 4 M HCl-dioxane (1 mL) at 0° C. and the resulting solution stirred at 25° C. for 2 hours. The mixture was concentrated and the residue triturated with ether giving a yellow solid (321 mg, 96%; HPLC (60/40) 2.24 minutes (98%); MS 215 (MH+, 100%).

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue triturated with ether giving a yellow solid (321 mg, 96%
  3. customHPLC (60/40) 2.24 minutes (98%)

Sources & evidence

ORD record
ord-cfc43b65c7f047afa188e2484c1ac6ca
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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