HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1872165Generated: October 27, 2026
1,4-Dioxane hydrochloride → (S)-2-Amino-N,N-dimethyl-4-phenyl-butyramide hydrochloride
https://huagongshe.com/reaction/1872165
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | (S)-(1-Dimethylcarbamoyl-3-phenyl-propyl)-carbamic acid tert-butyl ester | HCID 54369423 | — |
| Product | (S)-2-Amino-N,N-dimethyl-4-phenyl-butyramide hydrochloride | HCID 69688590 | — |
Reaction Steps
(S)-(1-Dimethylcarbamoyl-3-phenyl-propyl)-carbamic acid tert-butyl ester (235 mg, 0.8 mmol) was dissolved in 4 M HCl-dioxane (2 mL) at 0° C. The mixture was stirred at 25° C. for 1.5 hours, concentrated and the residue triturated with ether. Yield, 187 mg, 100%; HPLC (60/40) 2.31 minutes (99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06107329 |
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| Source dataset | uspto-grants-2000_08 |
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| ORD ID | ord-d987e04c6b9346cbbf6c2658da0b1732 |
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| Source note | uspto-grants-2000_08 |
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