1,4-Dioxane hydrochloride → HCID 69688248, compound

HRID 1872167Notes

Reaction equation

HRID 1872167 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:17](=[O:21])[N:18]([CH3:20])[CH3:19])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)(C)(C)C.[ClH:23].O1CCOCC1>>[ClH:23].[NH2:7][C@@H:8]([CH2:9][C:10]1[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=1)[C:17]([N:18]([CH3:20])[CH3:19])=[O:21]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 53913110HCID 53913110, compound

Product 1

HCID 69688248HCID 69688248, compound

Conditions

Temperature
25 °C

Procedure

(S)-[1-Dimethylcarbamoyl-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester (5.7 g, 18.5 mmol) was dissolved in 4M HCl-dioxane (7 mL) at 0° C. The mixture was stirred at 25° C. for 3 hours, concentrated and the residue triturated with ether. Yield, 5.23 g; HPLC (60/40) 3.32 minutes (98%).

Workup

  1. concentrationconcentrated
  2. customthe residue triturated with ether
  3. customYield

Sources & evidence

ORD record
ord-eabf2e71c30446c0926f88a331d03fed
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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