Boc-D-phenylalanine → HCID 7201349, compound

HRID 1872170Notes

Reaction equation

HRID 1872170 reaction equation
Cl.[CH3:2][NH2:3].[C:4]([NH:11][C@@H:12]([C:20]([OH:22])=O)[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5]>>[C:7]([O:6][C:4](=[O:5])[NH:11][C@@H:12]([C:20](=[O:22])[NH:3][CH3:2])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([CH3:10])([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 637610Boc-D-phenylalanineHCID 6364545Methylamine hydrochloride

Product 1

HCID 7201349HCID 7201349, compound

Procedure

Methylamine hydrochloride (3.1 mmol) and Boc-D-phenyl-alanine (2.8 mmol) were coupled according to Procedure A (0-25° C. reaction temperature, 144 hour reaction time, washed with acid first, then base) giving the product which was used without further purification. Yield 760 mg, 96%.

Workup

  1. custom0-25° C. reaction temperature, 144 hour reaction time
  2. washwashed with acid first
  3. custombase) giving the product which
  4. customwas used without further purification

Sources & evidence

ORD record
ord-3ad04d5b76ab4e9eb1da29d7743f21be
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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