1,4-Dioxane hydrochloride → HCID 69687394, compound

HRID 1872173Notes

Reaction equation

HRID 1872173 reaction equation
C(OC(=O)[NH:7][CH:8]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:9]([N:11]1[CH2:15][C@H:14]([OH:16])[C@@H:13]([OH:17])[CH2:12]1)=[O:10])(C)(C)C.[ClH:26].O1CCOCC1>>[ClH:26].[NH2:7][CH:8]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:9]([N:11]1[CH2:15][C@H:14]([OH:16])[C@@H:13]([OH:17])[CH2:12]1)=[O:10]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57154069HCID 57154069, compound

Product 1

HCID 69687394HCID 69687394, compound

Procedure

(3S,4S)-[1-Benzyl-2-(3,4-dihydroxy-pyrrolidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (360 mg, 1.00 mmol) was dissolved in 4 M HCl-dioxane (4 ml) at 25° C. for 3 hours. The mixture was concentrated and the resulting yellow solid triturated with ether and dried. Yield 304 mg, 103%.

Workup

  1. concentrationThe mixture was concentrated
  2. customthe resulting yellow solid triturated with ether
  3. customdried

Sources & evidence

ORD record
ord-045d69f1852743e598a5a209869beeb0
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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