Morpholine → HCID 15458722, compound

HRID 1872176Notes

Reaction equation

HRID 1872176 reaction equation
[C:1]([NH:8][C@H:9]([C:11]([OH:13])=O)[CH3:10])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.[OH-].[Na+]>>[C:4]([O:3][C:1](=[O:2])[NH:8][C@@H:9]([CH3:10])[C:11]([N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)=[O:13])([CH3:5])([CH3:6])[CH3:7]

Participants

4

Reactant 3

HCID 8083MorpholineHCID 14798Sodium HydroxideHCID 85082Tert-butoxycarbonylalanine

Product 1

HCID 15458722HCID 15458722, compound

Procedure

BOC-L-Alanine (3.50 mg, 20 mmol) and morpholine (1.74 g, 20 mmol) were coupled according to procedure A (washed with 1N NaOH after acid washes) giving a colorless oil which was used without further purification. Yield 3.94 g, 76%.

Workup

  1. customgiving a colorless oil which
  2. customwas used without further purification

Sources & evidence

ORD record
ord-56e606ed0c64406386068a4b2423147a
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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