HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-1H-indole-2-carboxylic acid → HCID 54395516, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-1H-indole-2-carboxylic acid | HCID 82693 | — |
| Reactant | Methyl 2-amino-2-methyl-3-phenylpropanoate | HCID 568302 | — |
| Solvent | dichloromethane N,N-dimethylformamide | HCID 22350042 | — |
| Product | HCID 54395516 | HCID 54395516 | — |
Reaction Steps
Racemic 2-amino-2-methyl-3-phenyl-propionic acid methyl ester (200 mg, 0.87 mmol) and 5-chloro-1H-indole-2-carboxylic acid (170 mg, 0.87 mmol) were coupled according to Procedure A (2:1 dichloromethane/dimethylformamide solvent) and the product purified by chromatography on silica gel eluted with 10% ethyl acetate in hexanes. Yield 286 mg, 89%; HPLC (60/40) 9.63 minutes (85%); TSPMS 371/373 (MH+, 100%);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06107329 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-b17010129274420598f363b5ebc9ef8b |
| Source note | uspto-grants-2000_08 |