反应详情

[(5-Chloro-1H-indole-2-carbonyl)-amino]-acetic acid methyl ester (100 mg, 0.40 mmol) was added to a saturated solution of ammonia in methanol (ca. 3 mL) at 25° C. The suspension was sonicated for 1 hour and the resulting solution concentrated. The residue was triturated with ether/hexanes and dried. Yield 77 mg, 77%; HPLC (60/40) 2.78 minutes (98%); PBMS 252/254 (MH+, 100%);

1. customThe suspension was sonicated for 1 hour
2. concentrationthe resulting solution concentrated
3. customThe residue was triturated with ether/hexanes
4. customdried
5. customHPLC (60/40) 2.78 minutes (98%)