HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl thiazolidine-2-carboxylate hydrochloride → HCID 53941519, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl thiazolidine-2-carboxylate hydrochloride | HCID 2737506 | — |
| Reactant | N-[(5-chloro-1H-indol-2-yl)carbonyl]glycine | HCID 11436686 | — |
| Solvent | dichloromethane N,N-dimethylformamide | HCID 22350042 | — |
| Product | HCID 53941519 | HCID 53941519 | 79% |
Reaction Steps
(±)-Thiazolidine-2-carboxylic acid methyl ester hydro-chloride (1.02 mmol) and [(5-chloro-1H-indole-2-carbonyl)-amino]-acetic acid (1.02 mmol) were coupled according to Procedure A (1:1 dichloromethane-dimethylformamide solvent) and the crude product triturated with 1:1 ether-hexanes giving a light yellow solid. Yield 79%; HPLC (60/40) 4.47 minutes (95%); TSPMS 382/384 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06107329 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-9d592212093f457188f3ae7b6d11c796 |
| Source note | uspto-grants-2000_08 |