5-Chloro-1H-indole-2-carboxylic acid → (+/-)-5-Chloro-1H-indole-2-carboxylic acid [1-(2-fluoro-benzyl)-2-oxo-2-thiazolidin-3-yl-ethyl]-amide

HRID 1872193Notes

Reaction equation

HRID 1872193 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([OH:13])=O)=[CH:5]2.[NH2:14][CH:15]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[F:30])[C:16]([N:18]1[CH2:22][CH2:21][S:20][CH2:19]1)=[O:17]>>[F:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[CH2:23][CH:15]([NH:14][C:11]([C:6]1[NH:7][C:8]2[C:4]([CH:5]=1)=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=2)=[O:13])[C:16](=[O:17])[N:18]1[CH2:22][CH2:21][S:20][CH2:19]1

Participants

3

Reactant 2

HCID 826935-Chloro-1H-indole-2-carboxylic acidHCID 21710707(+/-)-2-Amino-3-(2-fluoro-phenyl)-1-thiazolidin-3-yl-propan-1-one

Product 1

HCID 53633644(+/-)-5-Chloro-1H-indole-2-carboxylic acid [1-(2-fluoro-benzyl)-2-oxo-2-thiazolidin-3-yl-ethyl]-amide

Procedure

From 5-chloro-1H-indole-2-carboxylic acid and (±)-2-amino-3-(2-fluoro-phenyl)-1-thiazolidin-3-yl-propan-1-one. mp 216-217° C.

Sources & evidence

ORD record
ord-6f20a566c5a74f97bf56963eba0ea488
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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