5-Chloro-1H-indole-2-carboxylic acid → HCID 54571086, compound

HRID 1872199Notes

Reaction equation

HRID 1872199 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([OH:13])=O)=[CH:5]2.[NH2:14][CH:15]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=1)[C:16]([N:18]1[CH2:22][CH2:21][S:20][CH2:19]1)=[O:17]>>[O:17]=[C:16]([N:18]1[CH2:22][CH2:21][S:20][CH2:19]1)[CH:15]([NH:14][C:11]([C:6]1[NH:7][C:8]2[C:4]([CH:5]=1)=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=2)=[O:13])[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:31])([F:32])[F:33])[CH:25]=1

Participants

3

Reactant 2

HCID 826935-Chloro-1H-indole-2-carboxylic acidHCID 21710782HCID 21710782, compound

Product 1

HCID 54571086HCID 54571086, compound

Procedure

From 5-chloro-1H-indole-2-carboxylic acid and (±)-2-amino-3-(3-trifluoromethyl-phenyl)-1-thiazolidin-3-yl-propan-1-one. mp 205-207° C.

Sources & evidence

ORD record
ord-a12928c82a2a44a4b6387098cc26fc3a
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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