Methyl iodide → HCID 68571154, compound

HRID 18722Notes

Reaction equation

HRID 18722 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C@H:8]1[C@@H:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Br:19])[NH:11][C:10](=[S:20])[NH:9]1.[CH3:21][I:22]>CCO>[IH:22].[Br:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C@H:12]1[C@@H:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Br:1])[NH:9][C:10]([S:20][CH3:21])=[N:11]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 86596319cis-4,5-bis-(2-Bromophenyl)imidazolidine-2-thione

Product 1

HCID 68571154HCID 68571154, compoundYield 67.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of cis-4,5-bis-(2-bromophenyl)imidazolidine-2-thione (35) (0.51 g, 1.36 mmol) and methyl iodide (0.178 mL, 2.1 mmol) in abs. EtOH (20 mL) is heated at 90° C. overnight. The reaction mixture is cooled to rt, concentrated in vacuo, and the residue suspended in Et2O. The insoluble material is filtered to give 0.51 g of the product 52.

Workup

  1. concentrationconcentrated in vacuo
  2. filtrationThe insoluble material is filtered

Sources & evidence

ORD record
ord-9f3ed9785aad43958021acad44a4b2d9
Source dataset
uspto-grants-2010_06
Patent number
US07741493B2

Reaction notes

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