5-Chloro-1H-indole-2-carboxylic acid → HCID 53940501, compound

HRID 1872200Notes

Reaction equation

HRID 1872200 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([OH:13])=O)=[CH:5]2.[NH2:14][CH:15]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[CH:27]=1)[C:16]([N:18]1[CH2:23][CH2:22][CH:21]([OH:24])[CH2:20][CH2:19]1)=[O:17]>>[Cl:32][C:28]1[CH:27]=[C:26]([CH:31]=[CH:30][CH:29]=1)[CH2:25][CH:15]([NH:14][C:11]([C:6]1[NH:7][C:8]2[C:4]([CH:5]=1)=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=2)=[O:13])[C:16]([N:18]1[CH2:19][CH2:20][CH:21]([OH:24])[CH2:22][CH2:23]1)=[O:17]

Participants

3

Reactant 2

HCID 826935-Chloro-1H-indole-2-carboxylic acidHCID 21710882HCID 21710882, compound

Product 1

HCID 53940501HCID 53940501, compound

Procedure

From 5-chloro-1H-indole-2-carboxylic acid and (±)-2-amino-1-(4-hydroxy-piperidin-1-yl)-3-(3-chloro-phenyl)-propan-1-one. mp 98° C. dec.

Sources & evidence

ORD record
ord-f81be31d34a748adaeaee16398ee47e5
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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