1-Hydroxybenzotriazole → HCID 54058721, compound

Participants

Role	Name	HCID	Charge
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	5-Chloro-1H-indole-2-carboxylic acid	HCID 82693	—
Reactant	Methyl 2-(2-amino-3-phenylpropanamido)acetate	HCID 351658	—
Reactant	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Solvent	Acetonitrile	HCID 6342	—
Product	HCID 54058721	HCID 54058721	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

To 5.0 mmol of 5-chloro-1H-indole-2-carboxylic acid (50 mL of a 0.1 M solution in acetonitrile) was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (50 mL of a 0.10 M solution in acetonitrile, 5.0 mmol), 1-hydroxybenzotriazole (50 mL of a 0.10 M solution in acetonitrile, 5.0 mmol), followed by (2-amino-3-phenyl-propionylamino)-acetic acid methyl ester (50 mL of a 0.10 M solution in acetonitrile, 5.0 mmol). The reaction was agitated overnight at 80° C. and then concentated to dryness to give the title compound. HPLC RT 8.15 (65%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06107329
Source dataset	uspto-grants-2000_08
ORD ID	ord-e708c891d19b4b8d99b5d606d912e5d7
Source note	uspto-grants-2000_08