1,4-Dioxane hydrochloride → HCID 69688374, compound

HRID 1872214Notes

Reaction equation

HRID 1872214 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:9]([N:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12]1)=[O:10])(C)(C)C.[ClH:28].O1CCOCC1>>[ClH:28].[NH2:7][C@@H:8]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:9]([N:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12]1)=[O:10]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 69688105HCID 69688105, compound

Product 1

HCID 69688374HCID 69688374, compound

Conditions

Temperature
25 °C

Procedure

[(1S)-Benzyl-2-(1,3-dihydro-isoindol-2-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (88 mg) was dissolved in cold 4N HCl-dioxane (1.5 mL), stirred 2 h at 25° C., and the mixture concentrated. The residue was triturated with ether and dried (65 mg, 91%). TSPMS 267 (MH+, 100%).

Workup

  1. concentrationthe mixture concentrated
  2. customThe residue was triturated with ether
  3. customdried (65 mg, 91%)

Sources & evidence

ORD record
ord-3d4a00aecd0542b3a771196a2216a355
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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