3-(2-Ethoxycarbonyl-vinyl)-1-(4-methoxy-benzenesulfonyl)-azepane-2-carboxylic acid tert-butyl ester → 3-(2-Hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl)-azepan-3-yl)-acrylic acid ethyl ester
Reaction equation
C([O:5][C:6]([CH:8]1[CH:14]([CH:15]=[CH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:13][CH2:12][CH2:11][CH2:10][N:9]1[S:22]([C:25]1[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=1)(=[O:24])=[O:23])=O)(C)(C)C.[OH:33][NH:34]C(C1C(COC(=O)C)CCCCN1S(C1C=CC(OC)=CC=1)(=O)=O)=O>>[CH2:20]([O:19][C:17](=[O:18])[CH:16]=[CH:15][CH:14]1[CH2:13][CH2:12][CH2:11][CH2:10][N:9]([S:22]([C:25]2[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=2)(=[O:24])=[O:23])[CH:8]1[C:6](=[O:5])[NH:34][OH:33])[CH3:21]Participants
3
Reactant 2
Product 1
Procedure
3-(2-Hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl)-azepan-3-yl)-acrylic acid ethyl ester was synthesized from 3-(2-Ethoxycarbonyl-vinyl)-1-(4-methoxybenzene sulfonyl)-azepane-2-carboxylic acid tert-butyl ester in the same manner as the procedures used for the preparation of Acetic acid 2-hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl)-azepan-3-ylmethyl ester: MS (M+H)+ =427.
Sources & evidence
- ORD record
- ord-600d48c69b5e4503953255b97a81eaa4
- Source dataset
- uspto-grants-2000_08
- Patent number
- US06107291
Reaction notes
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