反应详情

To a stirred solution of 1-(4-Methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2,3-dicarboxylic acid 2-tert-butyl ester (1.17 g, 2.65 mmoL) in 26.5 mL THF at 0° C. was added triethylamine (0.406 mL, 2.915 mmoL) followed by isobutyl chloroformate (0.378 mL, 2.915 mmoL). This suspention was allowed to stir for one hour. The suspention was then filtered into a dropping funnel which was added dropwise to a previously prepared sodium borohydride (321 mg, 8,48 mmoL) solution in 1.63 mL of water at 0° C. After 2.5 hours the solvent was stripped and the residue was diluted with ethyl acetate and water. The solution was washed once with 0.5N HCL, the layers separated, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography (silica: 25% to 35% ethyl acetate in hexanes) to yield 3-Hydroxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid tert butyl ester; MS: (M+H)+ =398, (M+NH4)+ =415.

1. filtrationThe suspention was then filtered into a dropping funnel which
2. additionwas added dropwise to a previously prepared sodium borohydride (321 mg, 8,48 mmoL) solution in 1.63 mL of water at 0° C
3. waitAfter 2.5 hours the solvent was stripped
4. additionthe residue was diluted with ethyl acetate and water
5. washThe solution was washed once with 0.5N HCL
6. customthe layers separated
7. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
8. customThe solvent was evaporated under reduced pressure
9. customthe residue was purified by column chromatography (silica: 25% to 35% ethyl acetate in hexanes)