3-Benzyloxymethyl-1-(4-methoxy-benzene sulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid → 3-Benzyloxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid hydroxyamide
Reaction equation
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:16][CH:15]=[CH:14][CH2:13][N:12]([S:17]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)(=[O:19])=[O:18])[CH:11]1[C:28]([OH:30])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:31][NH:32]C(C1C(COC(=O)C)CC=CCN1S(C1C=CC(OC)=CC=1)(=O)=O)=O>>[OH:31][NH:32][C:28]([CH:11]1[CH:10]([CH2:9][O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:16][CH:15]=[CH:14][CH2:13][N:12]1[S:17]([C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=1)(=[O:19])=[O:18])=[O:30]Participants
3
Reactant 2
Product 1
Procedure
3-Benzyloxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid hydroxyamide was synthesized from 3-Benzyloxymethyl-1-(4-methoxy-benzene sulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid in the same manner as the procedures used for the preparation of Acetic acid 2 -hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepin-3-ylmethyl ester: MS (M+H)+ =447, (M+NH4)+ =464.
Sources & evidence
- ORD record
- ord-208eec48390c4b398f17fd3b0ef3aad4
- Source dataset
- uspto-grants-2000_08
- Patent number
- US06107291
Reaction notes
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