Acetic acid 2-hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepin-3-ylmethyl ester → 1-(4-Methoxy-benzenesulfonyl)-3-phenylsulfanylmethyl-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid hydroxyamide
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]2[CH2:18][CH:17]=[CH:16][CH2:15][CH:14]([CH2:19][S:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH:13]2[C:27]([OH:29])=O)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[OH:30][NH:31]C(C1C(COC(=O)C)CC=CCN1S(C1C=CC(OC)=CC=1)(=O)=O)=O>>[OH:30][NH:31][C:27]([CH:13]1[CH:14]([CH2:19][S:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:15][CH:16]=[CH:17][CH2:18][N:12]1[S:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)(=[O:11])=[O:10])=[O:29]Participants
3
Reactant 2
Product 1
Procedure
1-(4-Methoxy-benzenesulfonyl)-3-phenylsulfanylmethyl-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid hydroxyamide was synthesized from 1-(4-Methoxy-benzenesulfonyl)-3-phenylsulfanylmethyl-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid in the same manner as the procedures used for the preparation of Acetic acid 2-hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepin-3-ylmethyl ester: MS (M+H)+ =449, (M+NH4)+ =466.
Sources & evidence
- ORD record
- ord-55b41d87a75a4b1b9138588d0e89f259
- Source dataset
- uspto-grants-2000_08
- Patent number
- US06107291
Reaction notes
Loading…