3-Benzofuran-2-yl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid → 1-(4-Methoxy-benzenesulfonyl)-3-phenylsulfanylmethyl-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid hydroxyamide

HRID 1872255Notes

Reaction equation

HRID 1872255 reaction equation
O1C2C=CC=CC=2C=C1C1(C(O)=O)CCC=CCN1[S:17]([C:20]1[CH:25]=[CH:24][C:23](OC)=[CH:22][CH:21]=1)(=O)=O.[OH:31][NH:32][C:33]([CH:35]1[CH:41]([CH2:42]OC(=O)C)[CH2:40][CH:39]=[CH:38][CH2:37][N:36]1[S:47]([C:50]1[CH:55]=[CH:54][C:53]([O:56][CH3:57])=[CH:52][CH:51]=1)(=[O:49])=[O:48])=[O:34]>>[OH:31][NH:32][C:33]([CH:35]1[CH:41]([CH2:42][S:17][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:40][CH:39]=[CH:38][CH2:37][N:36]1[S:47]([C:50]1[CH:55]=[CH:54][C:53]([O:56][CH3:57])=[CH:52][CH:51]=1)(=[O:48])=[O:49])=[O:34]

Participants

3

Reactant 2

HCID 186896693-Benzofuran-2-yl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acidHCID 53873648Acetic acid 2-hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepin-3-ylmethyl ester

Product 1

HCID 186896661-(4-Methoxy-benzenesulfonyl)-3-phenylsulfanylmethyl-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid hydroxyamide

Procedure

1-(4-Methoxy-benzenesulfonyl)-3-phenylsulfanylmethyl-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid hydroxyamide was synthesized from 3-Benzofuran-2-yl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid in the same manner as the procedures used for the preparation of Acetic acid 2-hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepin-3-ylmethyl ester: MS (M-H)+ =441.

Sources & evidence

ORD record
ord-b03c08a2df904de3bd3d0f6b308481ca
Source dataset
uspto-grants-2000_08
Patent number
US06107291

Reaction notes

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