HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1872349Generated: October 30, 2026
Sodium Azide → 4-(Azidomethyl)-2,6-dihydroxymethyl-s-triazine
https://huagongshe.com/reaction/1872349
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 4-(p-Toluenesulfonylmethyl)-2,6-dihydroxymethyl-s-triazine | HCID 22323694 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(Azidomethyl)-2,6-dihydroxymethyl-s-triazine | HCID 22323643 | — |
Reaction Steps
4-(p-Toluenesulfonylmethyl)-2,6-dihydroxymethyl-s-triazine is dissolved in DMF and sodium azide (1.1 eq.) is added. The reaction mixture is heated to 50° C. for 4 hours. The DMF is removed under reduced pressure and the residue is partitioned between CH2Cl2 and water. The CH2Cl2 layer is separated and the water layer is extracted several times with CH2Cl2. The CH2Cl2 layers are combined, dried (MgSO4), and concentrated. The resultant residue is purified by silica gel flash column chromatography to give 4-(azidomethyl)-2,6-dihydroxymethyl-s-triazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06107482 |
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| Source dataset | uspto-grants-2000_08 |
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| ORD ID | ord-95566c8701344d88a48482a5d46e24f9 |
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| Source note | uspto-grants-2000_08 |
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